Studies by Italian neurologist Antonio Constantini, MD have used vitamin B1 (thiamine) between 600-1800 mg/d (60-80 kg/bw) to successfully treat the fatigue in chronic and autoimmune diseases such as multiple sclerosis, inflammatory bowel disease, Hashimoto’s thyroiditis, stroke, fibromyalgia and certain balance disorders (ataxia). Sometimes 100 mg of intramuscular vitamin B1 every 4-7 days is a good alternative to oral intake. Minimal side effects have been difficulty sleeping remedied by taking the vitamin B1 before 5:00 pm. If the vitamin B1 causes a racing heart beat this is resolved by lowering the dose. Blood thiamine levels were normal (serum levels and thiamine pyrophosphate) and vitamin B1 replacement still reduced fatigue. Vitamin B1 enhances energy production in the cell through enhancing carbohydrate (glucose) metabolism and mitochondrial function. Thiamine’s recommended dietary allowances (RDAs) are: Infants 0-6 months, 0.2 mg; infants 7-12 months, 0.3 mg; children 1-3 years, 0.5 mg; children 4-8 years, 0.6 mg; boys 9-13 years, 0.9 mg; men 14 years and older, 1.2 mg; girls 9-13 years, 0.9 mg; women 14-18 years, 1 mg; women over 18 years, 1.1 mg.
Abstracts on Chronic Diseases, Fatigue and Vitamin B1:
Thiamine and Hashimoto’s thyroiditis: a report of three cases.
High-dose thiamine improves fatigue after stroke: a report of three cases.
High dose thiamine improves fatigue in multiple sclerosis.
Thiamine and fatigue in inflammatory bowel diseases: an open-label pilot study.
Thiamine and spinocerebellar ataxia type 2.
High-dose thiamine improves the symptoms of fibromyalgia.
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